.50 AE (12.7x33 mm)

   .50 AE is a large caliber hand gun bullet, and is the most powerful handgun bullet ever made. 

.50 AE next to .22 LR

   The Desert eagle was the first gun ever chambered with this bullet, actually the cartridge is 0.547 inch (13.6 mm) and therefore Desert eagle mark XIX was designed specifically for this bullet.

.50 AE next to .32 acp

Performance:
   The maximum chamber pressure for this bullet is 248 MPa and can produce almost 2490 J of energy, 
This bullet is commonly used to hunt big targets like bears, and considered unnecessary powerful for tactical defence, but you can imagine if it can easily kill armoured bares what will it do to humans. :P
  The hollow points of this bullets can easily break a wide hole in trees, and can even break their trunks down, and FMJ bullets can go right through a 4 people standing in line.

.50 AE (left) compared to other popular bullets of handguns 9mm (right) looks puny compaired to it.